What Is Phosphatidylserine?

Phosphatidylserine is a fat-soluble compound found in high amounts in the brain, where it helps with cognitive function. This can be found in several foods, such as soy, white beans, chicken liver, and egg yolks. Phosphatidylserine is known as “one of the most effective and important nootropics we have available today” according to many experts [1].

Phosphatidylserine is an aminophospholipid which helps to renew and repair neurons. This leads to a sharper memory, feeling more alert, and having an overall clearer mind [2, 3]. Phosphatidylserine has been seen to also have anti-stress effects and to help improve golf performance [5].

With age, levels of phosphatidylserine decline, along with other measures of cognitive performance. This is where supplementation can come in to help.


How Does Phosphatidylserine work? 

Phosphatidylserine is mostly concentrated in brain cell membranes. Here it helps to maintain fluidity, support the receptors, and regulate neurotransmitters like acetylcholine and dopamine.

Top 3 Phosphatidylserine benefits that will change your life. Piskorz, Matthew. March 25, 2021. Structure of a cell membrane.


There are many ways in which phosphatidylserine works within the brain. First, it helps boost glucose metabolism within the brain (glucose is your brain’s fuel). It also helps to maintain healthy levels of nerve growth factor (NGF) in the brain [4].

Phosphatidylserine aids in neurogenesis, which is the creation of fresh new brain cells.

It also improves plasticity, which is the formation of new neural connections.

Furthermore, phosphatidylserine assists with neural repair. It provides ongoing maintenance and upkeep of your brain cells. It can detect the damaged brain cells, and then signal the immune system to begin their cleanup.

It helps to regulate neurotransmitters, such as acetylcholine, dopamine, serotonin, and norepinephrine.


But What Are The Benefits Of Me Taking Phosphatidylserine??

Phosphatidylserine can decrease stress by blocking the stress-induced signaling which stimulates the release of cortisol. There is strong evidence from studies showing that phosphatidylserine can improve memory, attention processing speed, and alertness. There is also strong evidence that phosphatidylserine has a protective effect against cognitive decline associated with age as well as with some disease states (Alzheimer’s). Phosphatidylserine can also help to improve ADD and ADHD. Furthermore, this compound has been seen to improve processing accuracy, which is the ability to not make errors during testing or information processing.


Where Is The Proof For All These Great Benefits?!

One study showed that supplementation with phosphatidylserine was associated with improvements in memory, learning processes, and time taken to complete tasks. Verbal immediate recall was also significantly improved. Participants who had relatively good cognitive performance to begin with (at baseline) saw significant improvements in their immediate and delayed verbal recall, and learning abilities [6].

Another study was done on individuals ages 50-69 with memory complaints. Cognitive decline was slowed, and dementia was improved.

In a study children ages 4-14 with ADHD were supplemented with 200mg phosphatidylserine daily for 2 months. The results of the study were that symptoms of ADHD were reduced, inattention and impulsivity were reduced, and short term auditory memory was improved [7].


NEURO(X) contains 150mg of phosphatidylserine per serving to help keep your neurons healthy and maintain functional cellular membranes!




  1. David Tomen/ Phosphatidylserine (PS) – Nootropics Expert.
  2. Kim, H.Y. et al. Phosphatidylserine in the Brain: Metabolism and Function. Prog Lipid Res. Author manuscript; available in PMC 2015 Oct 1.
  3. Parker, A.G. et al. The effects of IQPLUS Focus on cognitive function, mood and endocrine response before and following acute exercise. J Int Soc Sports Nutr. 2011 Oct 21;8:16.
  4. Naftelberg, S. et al. Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia. Published: December 20, 2016.
  5. Jäger, R. et al. The effect of phosphatidylserine on golf performance. J Int Soc Sports Nutr. 2007; 4: 23.
  6. Vakhapova V, Cohen T, Richter Y, Herzog Y, Korczyn AD. Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial. Dement Geriatr Cogn Disord. 2010;29(5):467-74. doi: 10.1159/000310330. Epub 2010 Jun 3. PMID: 20523044.
  7. Hirayama S, Terasawa K, Rabeler R, Hirayama T, Inoue T, Tatsumi Y, Purpura M, Jäger R. The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial. J Hum Nutr Diet. 2014 Apr;27 Suppl 2:284-91. doi: 10.1111/jhn.12090. Epub 2013 Mar 17. PMID: 23495677.